• St Alphonsus Liguori
  • Marian Conference
  • Picnic!


Welcome to the Cathedral of St. Mary of the Annunciation Roman Catholic Church.

We believe our parish is a sacred place where human and divine meet, where people of all ages gather to grow in the knowledge and love of our Lord Jesus Christ. We encourage you to be a part of our parish family as we receive spiritual nourishment, guidance, inspiration and strength.  We ask you to join in our spiritual journey where we share each other's joys and sorrows, help those who are struggling and hurt. We invite you to make new friends, to reach out and invite others to be a part of our community of believers.

If it's been awhile since you've been to church, click here for more information. 

We invite you to explore our website, and check out our Facebook page and most importantly stop by and visit Jesus in church! You are always welcome!

For information concerning our website, please contact Lisa Simmons,, 573-335-9347.


Mass Times

Saturday: 4:00 pm, 5:30 pm

Sunday: 7:00 am, 8:30 am,
10:30 am

Tuesday: 8:00 am, 5:15 pm

Weekdays:  6:00 am, 8:00 am

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Parish News

Keep up with our parish family here by viewing news announcements, activities, pictures and videos.

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Online Giving

Our parish has set up the ability to tithe and make donations electronically.  It’s easy to set up with our safe and effective offertory system.

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Get Involved

Get involved in our parish with liturgical ministries, church activities, and membership.

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Faith is a journey.

We, as Catholic Christians joyfully worship God in faith. We learn, live and share our faith with others, with Mary as our Model. We listen to the Holy Spirit and use our gifts and talents as stewards to love and serve God and one another on our faith journey.


You are invited to the first Marian Conference at St. Mary Cathedral, 615 William Street in Cape Girardeau Mo. on April 28th and 29th.  The agenda for the conference will include 5 speakers, Mass, Adoration, Confession, the Rosary and spiritual resources. The Marian Conference will convene Frid...

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Flyer Registration Form  
St Mary Cathedral School, Cape Girardeau, MO is seeking an Elementary Principal for the 2017-2018 School year. See below for qualifications and hiring process. Qualifications Job Hiring Process
Last Sunday our class of High School Confirmation Candidates met!  If you are in high school and you forgot about our meeting and would like to be confirmed next April, please email or call Lisa Simmons in the parish office: or 573-335-9347 right away.
Hear the school kids sing at Mass this week! click the link below:     Friday, Sept. 23, 2016
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Upcoming Events

Daily Readings

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